Hi, I’m Krishna

I’m a PhD student in chemical biology at the University of Illinois Urbana-Champaign, in Prof. Jefferson Chan’s lab. I build light-activated molecules that switch on only when a target molecule is present, then use them to map which proteins sit next to each other in cells, with a focus on inflammation and cancer.

I’m supported by the NIH Chemical Biology Interface Training Program fellowship, and have held the Janulis Graduate Fellowship and a Drickamer Research Fellowship.

Before Illinois, I earned my B.S. (Research) in Chemistry at the Indian Institute of Science in Bengaluru, where I worked on lipid nanoparticles for mRNA delivery, and spent a summer at Ruhr-Universität Bochum as a DAAD-WISE scholar.

Research

Nov 2025 – present

Graduate Research Assistant

Prof. Jefferson Chan, Department of Chemistry, University of Illinois Urbana-Champaign
  • Synthesizing gated organic photosensitizers that activate only when a specific analyte is present, for photo-proximity labeling.
  • Goal: map, in space and time, the protein interaction networks involved in inflammatory disease and cancer biology.
Mar 2024 – May 2025

Bachelor’s thesis: Advanced nanocarriers for therapeutics

Prof. Mrinmoy De, Department of Organic Chemistry, IISc Bengaluru
  • Made a library of ionizable lipids by click chemistry, formulated them into lipid nanoparticles, and measured size, surface charge and cytotoxicity.
  • Synthesized a self-assembling peptide by solid-phase synthesis, to attach to IR-responsive photosensitizers for photodynamic anticancer therapy.
  • Tested the antimicrobial activity of 2D-MoS₂ nanodots and studied how they work.
May – Jul 2024

DAAD-WISE research intern

Prof. Dr. Nils Metzler-Nolte, Inorganic Chemistry, Ruhr-Universität Bochum, Germany
  • Built a peptide-drug conjugate against HER2-positive breast cancer cells, including the targeting peptide by solid-phase synthesis.
  • Worked on the total synthesis of a copper-binding thiosemicarbazone (Dp44mT) derivative.
  • Docked the conjugate with GOLD and AutoDock.
Mar – Nov 2022

Dry Lab Coordinator, IISc iGEM team

Project Halocleen
  • Led modeling for an enzymatic system that removes harmful halocarbons from the environment; designed assays and ran a proof of concept.
  • Won a gold medal at the iGEM Grand Jamboree and a nomination for Best Climate Crisis project, Paris 2022.

Publications and patent

Granted patent (India): Baidya S, Behera P, Sarmah S, Bharadwaj K, Nag M, Chakraborty D, Varadarajan R, De M. Ionizable lipid, process of preparing same, and applications thereof. Patent No. 604980; granted 5 October 2026.

Bandyopadhyay S, Gardner S, Nyamkondiwa K, Varadhan H, Kelch P, Bharadwaj K, Lee M, Panda A, Mortenson A, Tajkhorshid E, Chan J. Targeted nitric oxide delivery reveals MDA-dependent ALDH1A1 regulation and drug resistance. Submitted, 2026.

Bharadwaj K, Sarmah S, De M. Peptide-based coacervates for stimuli-responsive drug delivery: design, mechanisms, and applications. Submitted. Preprint

Baidya S, Sarmah S, Nag M, Chakraborty D, Behera P, Bharadwaj K, et al. Triazole-engineered ionizable lipids reveal design principles for enhanced mRNA delivery and viral neutralization. Submitted.

Afzal F, Sheernaly N, Piepenstock F, Steinbrueck A, Bharadwaj K, et al., Metzler-Nolte N. Externally triggered activation of targeted peptide-thiosemicarbazone conjugates via cold atmospheric plasma. Submitted.

Chandana K, Bharadwaj K, et al., Girish YR. Construction of a bimetallic NiFe-PB functionalized with 2D-MoS₂ nano-heterojunction with NIR antibacterial activity. Submitted. Preprint

Awards and honors

Conferences

Teaching and mentoring

Two semesters

Teaching assistant, CHEM 233

Elementary Organic Chemistry Lab, University of Illinois
  • Ran lab training and safety for 45+ undergraduates and gave feedback on their lab reports.
Aug 2026 – present

Mentor

  • ACSxWCC Mentorship Program for undergraduate students.
  • Undergraduate mentor to Kyren Whiting, a junior in chemical engineering.
Nov 2022 – Nov 2023

Mentor and advisor, IISc iGEM 2023 team

Service and leadership

Oct 2026

Judge, ECI-ACS Undergraduate Research Conference

  • Coaching undergraduates on poster and oral presentations.
Jun 2023 – 2024

Climate x Youth Pioneer, Global Alliance of Universities on Climate

  • Organized talks and outreach sessions on climate change and sustainability.
Mar 2023 – Mar 2024

Convenor, Catalysts (IISc undergraduate chemistry club)

  • Organized lectures, student research talks and career sessions, and gave a lecture on biocatalysis and enzymology.
Mar 2023 – Feb 2024

Sci-Tech Coordinator, Pravega (IISc’s annual science and culture fest)

  • Organized the Pravega Innovation Summit for student innovators and early-stage teams.
2023 – 2025

Volunteer, IISc Open Day and RSC Yusuf Hamied Chemistry Camp

  • Ran chemistry demonstrations for school students and handled the finances of the 2023 undergraduate exhibit.